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10.1016/j.biopha.2022.114100 Biomed

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10.3389/fgene.2022.880359 81

S1PR modulators such as ozanimod and etrasimod, targeting this axis, induce S1PR1 internalization and degradation, blocking lymphocyte sensing of the S1P gradient, thereby reducing lymphocyte accumulation in peripheral blood and intestinal tissues

NLRP3 inflammasomes encompass a central nucleotide-binding and oligomerisation (NACHT) domain, which contributes to self-oligomerisation and has ATPase activity