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This impairment initiates a cascade of pathological events, including extracellular matrix remodeling, elevated intraocular pressure, aqueous humor outflow obstruction and the apoptosis of RGCs, ultimately resulting in vision loss (Pitha et al., 2024)

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GP (that is PDB 1GP1, according to Protein Data Bank, and EC 1.11.1.9, according to the Enzyme Commission numbering) is the main term of an enzyme family with peroxidase activity