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Interestingly, activation of autophagy as well as activation of apoptosis can be realized through MAP kinases such as ERK1/2, p38 and MAPK8/JNK1 (c-Jun N-terminal Kinase) (Fig

Uchima, M

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Furthermore, a higher incidence of ALI with a direct pulmonary source may be associated with a higher frequency of ARDS and a higher mortality rate [18, 84], possibly due to poorer respiratory mechanics and lung elastance when compared to indirect insults [85]