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The risk differences (drug versus placebo), however, were relatively stable within age strata and across indications

For instance, abnormalities in mitochondrial energy metabolism, impaired lysosomal degradation, and activation of the endoplasmic reticulum unfolded protein response not only promote abnormal Syn aggregation but also exacerbate oxidative stress and neuroinflammation, creating a vicious cycle

Reported benefits (per available research): Studied for its ability to raise GH and IGF-1 toward youthful levels and blunt age-related loss of fat-free mass, based on a 2-year randomized, placebo-controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine, PMID 18981485)

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