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Thirdly, the review lacks studies that directly link reported symptoms during initiation with physiological measures such as electrolyte loss or microbiome changes

Nat Rev Mol Cell Biol 4:517529 Metzler M et al (2013) Curcumin uptake and metabolism Bio Factors 39:1420 Park CB, Ahn CM, Oh S, Kwon D, Cho WC, Shin WS, Cui Y, Park BG, Lee S (2015) Synthesis of alkylsulfonyl and substituted benzenesulfonyl curcumin mimics as dual antagonist of L-type Ca 2+ channel and endothelail A/B 2 receptor

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Emerging findings also correlate its usage with a 1.7-fold higher fall risk in the elderly and synergistic opioid respiratory depression, demanding safer alternatives or precision dosage regimens [171,172,173]