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doi: 10.1210/en.2004-1064 278 YinHZhuQLiuMTuGLiQYuanJet al

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Given that AGERAGE signaling is known to activate inflammatory and oxidative pathways 76 , our findings support the interpretation that chronic dietary AGE exposure is associated with testicular redox imbalance

In one, multi-clinic, placebo controlled study employing an add-on design (adjunctive therapy), 144 patients who continued to suffer eight or more CPS per 8 weeks during an 8 week period of monotherapy with doses of either carbamazepine or phenytoin sufficient to assure plasma concentrations within the "therapeutic range" were randomized to receive, in addition to their original antiepilepsy drug (AED), either divalproex sodium or placebo