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For heavy smokers who previously consumed over a pack of cigarettes a day, starting with a nicotine strength of 18 to 20 mg/ml is often recommended to tackle nicotine cravings and withdrawal symptoms, as this can provide a similar level of nicotine to what they were accustomed to

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Le Foll B, Melihan-Cheinin P, Rostoker G, Lagrue G (2005) Smoking cessation guidelines: evidence-based recommendations of the French Health Products Safety Agency

A Japanese academic group for smoking cessation also said in April last year that IQOS emits harmful substances just like regular cigarettes and smoke-free e-cigarettes might raise the risk of secondhand smoking