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Finally, the impact of ADPKD-related systemic abnormalities (e.g., electrolyte disturbances, hypertension, and liver cysts) on ferroptosis pathways and therapeutic responses is unexplored, which may affect the translatability of preclinical findings

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This dual mechanism gives Tirzepatide a stronger metabolic effect and often leads to greater fat loss.

(Front row, left to right) Kenneth Nakamatsu, Renee Chang, Norman Ohara (alternate)