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Each spherical HDL particle has approximately 50-130 phospholipids, 10-50 free cholesterol molecules, 30-90 CE molecules, and 10-20 triglyceride (TG) molecules (536)

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When liver injury, inflammation, viral infection, steatosis, or toxin exposure occurs, ROS production increases (via mitochondria, NADPH oxidases, cytochrome P450 metabolism, peroxisomal oxidation) and antioxidant defenses may be overwhelmed, tipping the scale toward oxidative stress [11]