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However, several mechanisms appear to contribute, including glutamate excitotoxicity (Rothstein et al., 1990), oxidative stress (Barber et al., 1993

J Biol Chem 271:81018107 Becker K, Christopherson RI, Cowden WB, Hunt NH, Schirmer RH (1990) Flavin analogues with antimalarial activity as glutathione reductase inhibitors