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From enrolment and for the duration of the study, participants were able to report possible adverse events and intake of concomitant medication/supplements

During the first month on the 2.5mg starting dose, appetite suppression is noticeable but not overwhelming

Starting at the age of 10 months, these mice begin to display accelerated age-associated phenotypes seen in aging disorders in humans (Karuppagounder et al., 2017)