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In aerosolized form, MTB passes through the respiratory tract into the lungs and in most cases enters the distal alveolar cavities ( TB-specific granulomas are formed by the organized aggregation of different types of immune cells at the site of infection, in which there is a complex and dynamic interaction between MTB and the host ( When the immune function of the host is impaired, the core of the granuloma undergoes caseous changes and liquefaction in response to the accumulation of foam cells transformed from macrophages and a large number of necrotic host immune cells ( 2.1 Innate immunity in MTB infection 2.1.1 Macrophages Macrophages are an important component of TB pathogenesis, participating in early exposure to MTB and acting as a refuge for MTB during chronic infection

Representative images of Prussian blue staining of indicated E12.5 whole embryo sections (bottom)

Beaudry-RichardAAbdelhakASalonerRSaccoSMontesSCOertelFCet al