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BMJ article on ethical approval from 2009 bmj.com/content/338/bmj.b450 The letter just says in line with guidelines

Advanced protocols with the 60 mg vial Beyond standard titration, the 60 mg vial supports several advanced dosing strategies that smaller vials cannot practically accommodate

The lifetime of the MLCT state is inversely related to the size of the alkyl ligand: 1 ns (methyl), 48 ps (ethyl), 32 ps (n-propyl), and 14 ps (adenosyl, if the MLCT state is present).Excitation at 400 nm opens a pathway for direct photohomolysis of the carbon-cobalt bond in methyl-, ethyl-, and n-propylcobalamin

Gyermek, L., Soyka, L