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Preventing this decrease, with the administration of a SIRT-1 activator, reversed ROS bursts, increased downstream nuclear PGC-1a and Nrf2 expression, and attenuated increases in mitochondrial membrane potential and neuronal apoptosis induced by ischemia/reperfusion injury [78]

Once tumors reached a size of 100 mm 3 , mice were injected through the lateral tail vein with HEK293T derived Ctrl or OLFM4 over expressing MVs (1 10 9 MV particles in 100 l HEPES buffer) every other day

The HSV-1 VP5 signal remained undetectable during the first 60 min of infection, and then gradually increased at later time points

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