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In the United States it is not FDA-approved , and as of April 23, 2026 it was removed from FDA's 503A Category 2 list of bulk substances flagged for compounding safety risks because the underlying nominations were withdrawn

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In the second period, the differences to be negotiated are nicotinate and nicotinamide metabolism, phenytalanine metabolism and glutathione metabolism, which continue the change trend of the first period, and purine metabolism, butanoate metabolism, citrate cycle (TCA cycle) and alaine, aspartate and glutamate metabolism, which change significantly in this period