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Resistance to necroptosis, arises from the inactivation of essential regulators such as RIPK1 and RIPK3, resulting in treatment resistance in cancers including glioblastoma (Xie Y

Disclosures: David Lee: Nothing to Disclose, Caroline Klindt-Morgan: Nothing to Disclose, Dominick Hellen: Nothing to Disclose, Ashley Bennett: Nothing to Disclose, Paul Dawson: Nothing to Disclose, Saul Karpen: Albireo/Ipsen: Consultant, Mirum: Consultant, HemoShear: Consultant, Intercept: Consultant 718 THE USC PSYCHOSOCIAL CHECKLIST: A TOOL TO REMOTELY SCREEN POTENTIAL LIVER TRANSPLANT (LT) CANDIDATES WITH ALCOHOL-ASSOCIATED LIVER DISEASE (ALD) PRIOR TO HOSPITAL TRANSFER Brooke Edwards 1 Samantha Ramirez 1 John Pappas 2 Jennifer Dodge 2 Hyosun Han 3 Jeffrey Kahn 2 Norah Terrault 3 Aaron Ahearn 2 Brian Lee 4 , 1 Keck Medical Center of USC, 2 Keck USC, 3 University of Southern California, 4 Keck School of Medicine Background: ALD is the #1 indication for LT, leading to a rise in inter-hospital transfer requests for LT evaluation

Organisms like fish, which live in cool environments, have fats with more unsaturation and this is why fish oil contains polyunsaturated fatty acids

Muscular weakness, muscle wasting, and cardiomyopathy (inflammation and damage to the heart muscle) have been observed in these patients