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(v) alternatively, pyruvate may yield acetate through neomorphic activity of pyruvate dehydrogenase complex (or other dehydrogenases) in the presence of reactive oxygen species (ROS) 169,170 , that in turn yields acetyl-CoA by mitochondrial acetyl-CoA synthetase (Fig

Nonetheless, aging does not equally affect all physiological parameters and age-associated decline in sensory neurons functionality is for instance much faster than decline in locomotion 45

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This metabolic reprogramming enables cancer cells to tolerate elevated oxidative stress and becomes a key determinant of their survival