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Omega-3 index is directly associated with a healthy red blood cell distribution width. Prostaglandins, leukotrienes, and essential fatty acids vol

pro-apoptotic pathways, including the activation of caspases and prolonged c-Jun NH2 terminal kinase (JNK) signaling, are antagonized by various NF-B target genes 28

This indicates that the observed associations are not driven by demographic imbalance and that residual confounding or collider bias related to age and sex is unlikely to explain the results

Beyond classic bone-marrow suppression and transaminase elevation, four pulmonary-specific and systemic hazards demand particular vigilance in patients with LC: Radiation-like pneumonitis/fibrosis, iron-catalyzed oxidative stress, CD8+ T-cell functional exhaustion and QT-interval prolongation (144)