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The upregulation of several surface receptors reflecting activation markers (i.e., CD11b, CD11c, CD13, CD18, CD25, CD29, CD58, CD63, CD66e, CD67, CD108, CD123, HLA-DR, and TSLPR) was observed on eosinophils in the BAL and/or induced sputum of patients with allergic disease, which leads to increased inflammation (Johansson, 2014

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Furthermore, the observation that visual loss is associated with an increased longitudinal risk of AD diagnosis, with a greater risk observed when visual loss occurs earlier in the lifespan [228], accentuates the potential significance of aligning the endogenous melatonin rhythm with the light-dark cycle for optimal brain health in humans

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