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doi: 10.3389/fncel.2021.644126 119 MillerR

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Mice overexpressing wild-type human -synuclein display alterations in colonic myenteric ganglia and defecation

Immunochemistry Technologies, Cat # 941) for 1 h

In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated and because it consumes both the universal methyl donor (SAM) and the NAD precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]