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Transcript quantification was performed by mapping reads to the mm10 or hg38 cDNA reference using Salmon

NCOA4 can mediate ferritinophagy, while it is degraded via HERC2 ubiquitination-mediated induction of the proteasomal degradation machinery in the presence of iron ( FBXL5 E3 ubiquitin ligase mediated ubiquitination and proteasomal degradation ( Both, iron deficiency and iron overload lead to impaired hematopoietic functions

This is oxidized by the peroxide to SeOH subsequently trapped by a GSH molecule to give Se-SG and by another GSH molecule to Se - again, releasing a GS-SG by-product