mitochondrial glutathione regulation and functions Glutathione: Mitochondrial Glutathione in Cellular Redox

The broad spectrum of substrates means GST activity has been implicated as a determinant of efficacy for many drugs [2,3], with isoenzyme, GST P1-1 most commonly associated with both innate and acquired drug resistance during cancer chemotherapy [1,4,5], including 5-fluorouracil- and cisplatin-resistant gastric cancers [6] and doxorubicin-resistant prostate cancer [7], because of overexpression in drug-resistant cell lines [8,9]

152 Insulin stimulates increased production of androgens in theca cells isolated from women with PCOS, which effect is mediated by the insulin receptor

Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors

A similar result was reported by another single-blind, randomized, and standard-controlled clinical trial of 40 patients and open observational clinical trial of 30 patients, based on both pre- and post-stroke Stroke Rehabilitation Assessment of Movement (STREAM) criteria