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These include determining the precise location and physiological significance of the allosteric binding sites, investigating whether these compounds can stabilize specific conformations of the transporter, understanding how different conformations of EAATs transmit signals into the cell, and exploring the possibility of allosterically modulating transporter-mediated efflux

For instance, research shows that HRD tumor cells, after platinum treatment, may evade drug effects by restoring HRR functionality or upregulating multi-drug resistance-related genes ( Furthermore, changes in the tumor microenvironment, intercellular signaling, and gene expression alterations can also promote the development of resistance

The trust's consultant geriatrician and service lead for Parkinson's, Dr Nishantha Silva, said: "We are proud to be the first trust in the East Midlands to offer this and aim to build on this success by expanding access to Produodopa