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33,38,42,44,46,47 In line with these observations, mathematical modelling using data from treatment-nave patients predicted that the primary tumours and their metastases share the same driver mutations

The TCA cycle is completed by MDH, which, as a salt-sensitive enzyme, is thought to play a protective role by counteracting the damaging effect of salt by increasing the malate through conformational change (Saha et al., 2012)

PHGDH enzyme: a novel target for cancer treatment The serine synthesis pathway has been widely reported to be strongly associated with cancer proliferation and metastasis, although the specific mechanism underpinning the functional addiction of some tumour cells to serine remains uncertain 11