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Think of that American Cancer Society poster featuring the ravaged older woman, puffing away, with the slogan, Smoking is very glamorous. Cruise the Internet a bit, and youll find images that are even more jolting

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Unlike the nuclear genome, mitochondrial genomes lack histones, therefore, rather than histone-related modifications, research on mitochondrial gene expression regulation focused on mtDNA methylation and has demonstrated its differences in aging [35, 36] and various diseases including metabolic disorders [37, 38], neurodegeneration [39], and cardiovascular diseases [36, 40]