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In human and mouse IBD samples, ferroptosis-related genes are significantly upregulated, total ROS and lipid ROS levels are elevated in parallel, and the final product 4-hydroxynonenal(4-HNE) accumulates in large amounts [148]

For example, rheumatoid arthritis patients exhibit increased joint inflammation, pain, and stiffness in the early morning hours, which results from nighttime synthesis and release of proinflammatory cytokines and chemokines, leading to increased cell migration to inflamed tissues during this time [62]

iScience 27 , 109504 (2024)

This can also prevent the bowel from absorbing nutrients effectively