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These Phase II conjugates can be thought of as having chemical labeling tags which notify cells that the molecule is to be disposed of

However, it can cause flushing as a side effect

Here, we employed comparative global metabolomics to demonstrate that metabolism of the antioxidant glutathione (GSH) is inextricably linked to redox-active processes that facilitate melanin production, and that genetic perturbations in GSH biosynthesis affect fungal growth and virulence in a murine model of cryptococcosis