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The high GSH/GSSG ratio provides the essential reducing environment inside the cell

Abstract The mammalian target of rapamycin (mTOR) pathway is a central regulator of cellular growth, metabolism, and homeostasis, integrating a wide array of intracellular and extracellular cues, including nutrient availability, growth factors, and cellular stress, to coordinate anabolic and catabolic processes such as protein, lipid, and nucleotide synthesis

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Finally, since ROS production can be partially controlled positively or negatively by nutrition and/or by pollutants, it remains to be established how environmental factors could be incorporated into treatment strategies