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Role of v3 Integrin in Fibronectin Fibrillogenesis v3 integrin activation in cultured HTM cells increased the deposition of the alternatively spliced form of fibronectin called EDA + fibronectin (Filla et al., 2019) that is associated with the ECM changes observed in POAG and thought to contribute to elevated IOP (Roberts et al., 2020)

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A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis