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These pharmacokinetic constraints contribute to difficulty achieving in-vivo concentrations comparable to those seen in mechanistic in-vitro studies

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In addition, selenium dioxide (LC50 = 6.7 mg/L) had a lower LC50 relative to SeNPs (LC50 = 41.0 mg/L)

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COPD patients who will most likely benefit from nebulization therapy are included in Table 2 (adapted from ref

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