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Addiction 115:11411148 Jacob P III, Yu L, Duan M, Ramos L, Yturralde O, Benowitz NL (2011) Determination of the nicotine metabolites cotinine and trans-3-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatographytandem mass spectrometry: biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity

Because one pack contains 20 cigarettes

Once the patch is adhered cohesively to skin around all edges, it can almost be forgotten until time to change it

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