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Fowler, B., Leonard, J

2011 Sep;94(3):938-44

Primary pain in ALS includes neuropathic pain and pain due to spasticity or cramps, whereas secondary pain is mainly nociceptive and may appear as muscle weakness and atrophy progress [83]

This self-perpetuating cycle of mitochondrial damage and oxidative injury progressively worsens mitochondrial pathology, constituting a key mechanistic driver of MMA-associated neurological damage (Dimitrov et al