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Potential implications of the new pharmacotherapies on obesity management The mean WL in clinical trials with the most efficacious new obesity pharmacotherapies ranges between 15% and 25% at 1 year (and it may be even higher for some agents that have not reached weight plateau at study completion)

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Funnel plots suggest publication bias in studies of only one of the five variants considered (i.e., the GSTM1 null genotype), but it is difficult to exclude this bias in studies of the four other variants despite our attempts to identify un-reported data by correspondence with investigators and exploration of data for the possible effects of selective publication

doi: 10.1089/ars.2014.5994