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May-Panloup P, Boucret L, de la Chao Barca JM, et al

Immune dysfunction and increased oxidative stress state in diet-induced obese mice are reverted by nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids

Whereas, n-3 PUFA oxidation produces less inflammatory compounds such as PGE3 and LTB5, following COX oxidation and lipooxygenase activity (150)

Similar trends were observed in a mouse model of pancreatic ductal adenocarcinoma (PDAC) ( LSL-Kras G12D/+ Trp53 f/f Pdx1 cre (KP / C) mice 28 ) and in humans with renal cell carcinoma 29 (Extended Data Fig