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The example of amyotrophic lateral sclerosis

Considerable evidence indicates that cerebral glucose uptake is impaired in ALS patients 13

UrawaMKobayashiTD'Alessandro-GabazzaCNFujimotoHTodaMRoeenZet al

The Gut BarrierSystemic Inflammation Axis, appearing repeatedly across multiple studies as a common endpoint across modules, represents a critical locus, yet its directionality and necessity within the causal chain await clarification through longitudinal and blocking research