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Heightened or overexaggerated responses to stimuli such as jumping and feeling pain when something very light touches your skin

The mouse was removed from the maze and returned to its home cage for 1 min

In addition to the co-delivery of therapeutic agents with siRNA or new-generation potent P-gp inhibitors mentioned above, co-delivery of therapeutic agents with natural alkaloids (such as tetrandrine, quercetin (QUE), kaempferol, and icaritin) may be a good strategy when facing the failure of first- and second-generation P-gp inhibitors (such as verapamil, cyclosporine A, and dexverapamil) ( 2.2 Inducing cell apoptosis in cancer therapy Apoptosis is programmed cell death that is initiated after damage to DNA and cell organelles, such as the mitochondria and endoplasmic reticulum ( In vivo TUNEL assays also showed that tumors in the CDDP/CUR-Lip group had the largest proportion of apoptotic tumor cells

They differ significantly in their composition, clinical evidence base, and cost