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Targeting FASN can deprive cancer cells of membrane biosynthesis substrates, while CPT1 inhibition blocks mitochondrial fatty acid entry, thereby reducing ATP production in FAO-dependent tumors

As with Keshan disease, KBD is prevalent in selenium-deficient provinces and thus generally affects people with very low selenium intakes (58, 59)

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261 Several PMO-based NADs have been approved for treating DMD, including eteplirsen (Exondys 51), 262 golodirsen (Vyondys 53 ), 80 viltolarsen (Viltepso ), 263 and casimersen (Amondys )