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Human studies demonstrate sustained, dose-dependent increases in both GH and IGF-1 with subcutaneous administration [1]

This approval has since been discontinued (the FDA withdrew approval in 2008 due to a manufacturing business decision, not safety concerns), but compounded Sermorelin remains widely used in adult clinical protocols under physician prescription

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Figure 3: Kaplan-Meier Curves for Overall Survival in Non-Squamous NSCLC in Study JMDB Figure 4: Kaplan-Meier Curves for Overall Survival in Squamous NSCLC in Study JMDB Maintenance Treatment Following First-line Non-Pemetrexed Containing Platinum-Based Chemotherapy The efficacy of pemetrexed as maintenance therapy following first-line platinum-based chemotherapy was evaluated in Study JMEN (NCT00102804), a multicenter, randomized (2:1), double-blind, placebo-controlled study conducted in 663 patients with Stage IIIb/IV NSCLC who did not progress after four cycles of platinum-based chemotherapy