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10.1136/bjophthalmol-2016-309814 133

Injectable vs

However, ICIs have shown limited efficacy in treating PDAC, predominantly because of the hostile TME characterized by fibrosis, hypoxia, and immunosuppression [148]

Moreover, simvastatin also enhances ex vivo the tumor cell inhibition effects of cisplatin or docetaxel in head and neck squamous carcinoma (HNSCC) (227) and sensitized human osteosarcoma cells to doxorubicin and cisplatin (228)