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To comprehensively understand and harness metformins antioxidative potential, additional multicenter clinical trials involving diverse patient populations and varied medical contexts are essential

There are three major types of autoantibodies found in type 1 diabetes such as GDP65, IA2, and insulin autoantibodies, but antibodies against insulin can be identified mostly in young patients and may be lacking in adults [52, 53]

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For immunofluorescence analysis of NK cell viability in mouse lungs, the engrafted human NK cells were detected using anti-human CD56 antibody (1:100) with a Two-step IHC Detection Kit (ZSGB-BIO), followed by amplification with tyramide (1:200) using Opal 690 Reagent Pack (AKOYA) according to the manufacturers instructions