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The RESTORE (Reducing Exacerbations and Symptoms by Treatment with Oral Erdosteine in COPD) placebo-controlled study demonstrated that erdosteine administered twice daily at the approved dose (300 mg twice daily) and added to usual maintenance therapy for 12 months, reduced the overall exacerbation rate in patients with moderate or severe COPD and a history of exacerbations in the previous year, many of whom were already receiving ICS [95]

HIV-Tat is known to interact with histone acetyl transferase Tip60 (Tat-interacting protein 60 kDa), an important player in the DNA Damage Response

2014;35(11):e265826515

Moreover, small chemical groups can covalently attach Ub to form phosphorylation, acetylation, deamidation, ADP ribosylation, and phospho-ribosylation of Ub (Mattiroli and Penengo 2021)