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Differential Diagnosis Considered etiologies included: Primary psychiatric disorder Neuroinflammatory or neurodegenerative disease Endocrine dysfunction Chronic infection (Lyme disease, EBV) Chronic inflammatory response syndrome (CIRS) Environmental toxin exposure (including mycotoxins) The acute onset, lack of psychiatric history, and environmental correlation made a primary psychiatric etiology less likely

SURF1 mutant DNs exhibited reduced sodium and potassium currents compared to CTL DNs, lacked repetitive spiking and postsynaptic currents, and showed an increase in the number non-spiking neurons