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Its ability to intervene upstream at the level of transcriptional regulation and chromatin architecture marks it as more than a telomerase hack

Y.WuP.WenT.QinX.ZhangR.JiaR.et al

Moreover, -catenin recruits the transcription factor TCF4 to enhance SHMT2 expression, forming a positive feedback loop that sustains oncogenic signaling and promotes colorectal cancer cell proliferation and metastasis [139]