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In contrast to mice on a chow diet, glucose disposal was not significantly different between genotypes (Fig

As for DED, our previous research acknowledged that AST suppresses inflammation by downregulating the expression of HMGB1 and inflammation in DED models via the PI3K/Akt signaling pathway (Li et al., 2020)

New England Journal of Medicine (2025) 2

The VIGS-mediated high throughput methodology that we have described in this manuscript has several advantages to analyze the functional role of putative stress-induced genes