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Potential users should be aware that while preclinical safety appears excellent, the absence of extensive human clinical trials means unknown risks may exist

These inconsistent results also translate to human studies where obesity and steatosis correlated with increased hepatotoxicity after an APAP overdose in some studies [181] and no correlation of toxicity with obesity was observed in other studies [182]

[00237] In yet still other embodiments, the composition comprises at least one skin conditioning agents