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Up-stream regulators range from classical cytokines (TNF-) and stress pathways (PERK, NF-B) to lysosomal (GLMP), epigenetic (PRMT8) and metabolic (ApoB-100/SORT1) checkpoints, all feeding into a self-propagating loop of iron accumulation, oxidative damage and inflammatory polarization

First, researchers should investigate the efficacy of different EA waveforms, comparing intermittent and dense-disperse waveforms, along with exploring the effectiveness of various EA frequencies, such as 1 Hz versus 100 Hz

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doi: 10.1016/j.bioactmat.2020.09.011 75 JohnsonTKZhaoLZhuDWangYXiaoYOguljahanBet al