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Br J Pharmacol 154, 529-41 (2008)

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Sniderman AD, Williams K, Contois JH, Monroe HM, McQueen MJ, de Graaf J, Furberg CD

Indeed, dyslipidemia can lead to impaired penile endothelial function, thereby affecting erection, through multiple mechanisms: oxidation of low-density lipoprotein (LDL) leading to stimulation of endothelial cells to release endothelin and reactive oxygen species (ROS), which further reduce NO bioavailability ( In a study of 40 premenopausal women and 40 age- and BMI-matched men ( 4.2 Atherosclerosis Dyslipidemia, particularly LDL-C elevation, causes lipid deposition in the arterial wall, triggering plaque formation ( The penile cavernous arteries are small in diameter (about 0.3-0.5 mm) and particularly susceptible to atherosclerosis