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A recent investigation revealed that the expression of VRK2 was upregulated in response to ROS signals, while the link between VRK2 and metabolic rewiring remains obscure [18].In this study, we tried to explore the effects of VRK2 on the rewiring of metabolic networks and identify metabolic vulnerabilities resulting from VRK2-driven metabolic reprogramming

Despite increasing awareness and significant research advancements, treatment options comprise dopamine repleting, symptomatic therapies that have significantly increased quality of life and life expectancy, but no therapies that halt or reverse disease progression, which remain a great, unmet goal in PD research