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Mechanobiology is an emerging field that combines biology and bioengineering to study how physical forces and changes in mechanical properties of cells contribute to cell development, differentiation, proliferation and disease

TPENs strong zinc-binding affinity enables it to virtually eliminate the entire zinc response pool, a condition not attainable under normal or pathological circumstances, leading to predictable cell death

Regardless of the use of multiple off label therapies, participants living with PBC globally had evidence of ongoing moderatesevere pruritus, underscoring the unmet need for a symptom-specific therapy targeting pruritus in PBC

Patience and commitment are essential, but the results are worth it