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In glaucomatous eyes, studies have reported increased TNF- protein levels, elevated TNF- gene expression in glial cells, and upregulated TNF- receptor 1 in RGCs [65]

Microbes possess antibiotic degrading enzymes such as beta lactamase, esterase, nitroreductases, hydroquinone dioxygenase, ammonia monooxygenase, laccase, peroxidase and peroxygenase showing their evolutionary modification in response to the selective pressures of antibiotic exposure